TY - JOUR T1 - Longitudinal follow-up of quadriceps strength and function in a COPD cohort after 3 years JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00707-2017 VL - 50 IS - 2 SP - 1700707 AU - Sara C. Buttery AU - Divya Mohan AU - Marie Fisk AU - Nicholas S. Hopkinson AU - Ruth Tal-Singer AU - Ian B. Wilkinson AU - Michael I. Polkey Y1 - 2017/08/01 UR - http://erj.ersjournals.com/content/50/2/1700707.abstract N2 - Skeletal muscle weakness is a distinct extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD), which is associated with a poor prognosis [1] and may represent a novel therapeutic target [2]. However, there are only sparse longitudinal data from prospective studies on skeletal muscle weakness and its relationship with disease progression in COPD. Previous studies have been cross-sectional in nature, and have failed to correlate data with baseline measures of exercise performance or systemic inflammation.The short physical performance battery may be a useful endpoint in assessing impact on skeletal muscle dysfunction http://ow.ly/xf8z30dOFMz ER -