Abstract
Preeclampsia is associated with an increased risk of bronchopulmonary dysplasia, wheezing and asthma in later childhood. Currently, there are no studies available investigating maternal blood pressure measurements during multiple time points in pregnancy and respiratory outcome measures in the child. We examined the associations of maternal blood pressure and hypertensive disorders with the risk of lower lung function, wheezing and asthma in children aged 10 years. This study among 4894 children was embedded in a population-based prospective cohort study. We used multivariate analyses, taking lifestyle and socio-economic factors into account. We observed consistent associations per 5 mmHg higher maternal blood pressure in early pregnancy with a lower FEV1/FVC (Z-score (95% CI) −0,03 (−0,05, −0,01)), and per 5 mmHg higher blood pressure in late pregnancy with a higher risk for current wheezing and current asthma: (odds ratios (95% CI): 1.07 (1.02, 1.12) and 1.06 (1.00, 1.11), respectively). We found no associations of maternal hypertensive disorders during pregnancy with child lung function, current wheezing or current asthma.
Our results suggest that higher blood pressure in pregnant women is associated with lower lung function and increased risks of current wheezing and current asthma in children. The associations may be trimester specific.
Footnotes
This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.
Conflict of interest: Dr. Wilmink has nothing to disclose.
Conflict of interest: Dr. den Dekker has nothing to disclose.
Conflict of interest: Dr. de Jongste has nothing to disclose.
Conflict of interest: Dr. Reiss has nothing to disclose.
Conflict of interest: Dr. Jaddoe has nothing to disclose.
Conflict of interest: Dr. Steegers has nothing to disclose.
Conflict of interest: Dr. Duijts reports grants from European Union's Horizon 2020 co-funded programme ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL), grants from European Union's Horizon 2020 research and innovation programme , during the conduct of the study.
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